Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A.
نویسندگان
چکیده
The solid phase total synthesis of the marine cyanobacterial Ahp-cyclodepsipeptide Symplocamide A is reported as a model for a general route for the synthesis of tailor-made non-covalent serine protease inhibitors.
منابع مشابه
Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease Inhibitors.
The S1 serine protease family is one of the largest and most biologically important protease families. Despite their biomedical significance, generic approaches to generate potent, class-specific, bioactive non-covalent inhibitors for these enzymes are still limited. In this work, we demonstrate that Ahp-cyclodepsipeptides represent a suitable scaffold for generating target-tailored inhibitors ...
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عنوان ژورنال:
- Chemical communications
دوره 46 46 شماره
صفحات -
تاریخ انتشار 2010